Our overclocked Core i5-3570K feels right at home. The chip's either enjoying the trio of front intakes or the partly open-air design. Either way, CPU cooling performance isn't an issue.
Keeping our dual GTX 970s from reaching their 80ºC target is a challenge for a fair few cases. The 570X RGB kept GPU core temp to 79ºC for a good while but the GeForce cards had to throttle slightly once temperature reached the limit.
CPU and GPU cooling performance isn't going to be a problem on a case of this size and with this many fan/radiator mounting opportunities. The more pressing concern is acoustic, as the enclosure does little to prevent noise from leaking to the user. The default configuration is clearly audible when idle and bordering on loud when gaming, and there's no easy way to keep noise levels in check.