Crysis
The promise of silky-smooth Crysis gameplay at 2,560x1,600 remains unfulfilled.
The nature of the engine is such that the GTX 280 struggles at 1,920x1,200 HQ - and that's with no antialiasing or anisotropic filtering applied.
What's more, it's toppled by the twin guns of the GX2.
Yes, you can add a second or third GTX 280, but the game doesn't scale particularly well in multi-GPU mode.